Leslie Sharkey

Research/Areas of Interest

My primary research training is in animal models of cardiovascular disease, however I have expanded that to a general interest in toxicologic and medical device related clinical pathology. Specifically, recent areas of interest include the effects of radiation and chemotherapy on the cardiovascular system. Clinically, I am interested in novel approaches in coagulation testing and optimization of other laboratory diagnostic modalities in veterinary species.

General Research Interests
- Validation and diagnostic performance of clinical laboratory testing
- Coagulation
- Cytology
- Chronic complications of cancer treatment in animal models

Selected Research Projects
- Validation and diagnostic performance characteristics of turbidometric clot waveform analysis in veterinary coagulation (canine, feline, avian)
- Anticancer effects of resveratrol in canine hemangiosarcoma cell lines
- Cytologic and ultrasound evaluation of canine kidney disease
- Cytologic findings and diagnostic yield in 92 dogs undergoing fine needle aspiration of the pancreas
- Sex-dependent alteration of cardiac cytochrome P450 gene expression by acute doxorubicin toxicity in C57Bl/6 mice
- The interplay between genetic background and sexual dimorphism of doxorubicin-induced cardiotoxicity
- Platelet count and plateletcrit in Cavalier King Charles Spaniels and Greyhounds using the Advia 120/2120
- A pilot study evaluating the prognostic utility of platelet indices in dogs with septic peritonitis

Research and Clinical Interests
- Validation and optimization of laboratory testing
- Clinical pathology of domestic and laboratory animal species
- Animal models of human disease
- Toxicologic pathology