Leadership at Cummings School

Veterinary and comparative clinical pharmacology Comparative molecular toxicology Comparative pharmacogenetics Idiosyncratic adverse drug reactions Drug classes of particular interest include NSAIDs, anti-epileptic drugs, and antimicrobials

Internal medicine Comparative endocrinology Metabolism Nutrition Gastroenterology

Pathophysiology of Equine Gastrointestinal Disease

Wildlife medicine and surgery with an emphasis on seabird biology; the effects of oil pollution on wildlife; marine ecosystem health; SEANET; Petroleum toxicity; Wildlife analgesia

Tick-borne diseases with an emphasis on host-tick-Rickettsia interactions using a guinea pig model.

My primary research training is in animal models of cardiovascular disease, however I have expanded that to a general interest in toxicologic and medical device related clinical pathology. Specifically, recent areas of interest include the effects of radiation and chemotherapy on the cardiovascular system. Clinically, I am interested in novel approaches in coagulation testing and optimization of other laboratory diagnostic modalities in veterinary species. General Research Interests - Validation and diagnostic performance of clinical laboratory testing - Coagulation - Cytology - Chronic complications of cancer treatment in animal models Selected Research Projects - Validation and diagnostic performance characteristics of turbidometric clot waveform analysis in veterinary coagulation (canine, feline, avian) - Anticancer effects of resveratrol in canine hemangiosarcoma cell lines - Cytologic and ultrasound evaluation of canine kidney disease - Cytologic findings and diagnostic yield in 92 dogs undergoing fine needle aspiration of the pancreas - Sex-dependent alteration of cardiac cytochrome P450 gene expression by acute doxorubicin toxicity in C57Bl/6 mice - The interplay between genetic background and sexual dimorphism of doxorubicin-induced cardiotoxicity - Platelet count and plateletcrit in Cavalier King Charles Spaniels and Greyhounds using the Advia 120/2120 - A pilot study evaluating the prognostic utility of platelet indices in dogs with septic peritonitis Research and Clinical Interests - Validation and optimization of laboratory testing - Clinical pathology of domestic and laboratory animal species - Animal models of human disease - Toxicologic pathology

• Role of prostaglandins in retained fetal membranes and postpartum metritis in cattle • Therapy of postpartum metritis in cattle • Use of progesterone monitoring to predict parturition times in cattle and camelids • Efficacy of J-5 E. coli vaccines on the incidence and severity of coliform mastitis in dairy cows • Superovulation protocols for sheep and goats • Cryopreservation of sheep and goat semen • Preservation of livestock genetic resources

Virology, emerging infectious diseases, and disease ecology; comparative genetics, immunogenetics, and genetic mechanisms of infectious disease and health; comparative medicine, evolution of immune function, and host/pathogen interaction; veterinary and human public health; veterinary immunology and virology; genetic diversity