The Yang Laboratory at Cummings School of Veterinary Medicine at Tufts University investigates the role that epitranscriptomics plays in the development of veterinary cardiovascular diseases, such as canine myxomatous valvular disease, cardiomyopathies, and anti-cancer therapy-associated cardiovascular toxicities, and how manipulation of epitranscriptomics can be used to address these diseases therapeutically. Epitranscriptomics relates to the biochemical modification of RNA (transcriptomes) within the cells that will affect gene expression without changing the actual ribonucleotide sequences. Epitranscriptomic modification can occur via non-coding RNA (ncRNA) such as miRNA. miRNAs are short ncRNAs that can silence mRNAs and stop the translation of mRNAs into proteins. Our lab specifically focuses on miRNAs contained within extracellular vesicles, i.e., signaling packages produced by normal or diseased cells, which provide information related to the pathologic state of the cells.
Our aims are to better understand the pathophysiology of veterinary cardiovascular diseases and disorders, discover therapeutic targets, and apply the knowledge gained from veterinary patients to human diseases.
Patients of veterinarians and physicians both experience similar problems with respect to disease pathology, clinical symptoms, time-course, and patient management. Therefore, spontaneous disease models in veterinary patients (dogs, cats, horses, sheep, goats) are particularly useful to test the biological activity and therapeutic potential of extracellular vesicles. As part of Cummings School of Veterinary Medicine at Tufts University and as an affiliate of the veterinary hospitals, we are in a unique position to study spontaneous veterinary disease processes and relate these findings to human health.
The Yang Laboratory also provides research support to the Department of Clinical Sciences faculty, trainees and their collaborators. For specific information on resources listed below, call (508) 887-4589.
We are proudly supported by the following organizations and institutions.
Vicky Yang (Vicky.firstname.lastname@example.org)
Laboratory Manager: Dawn Meola (email@example.com)
Cummings School of Veterinary Medicine at Tufts University
200 Westboro Road, Building 21
North Grafton, MA 01536