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Molecular Helminthology Laboratory

Schistosome – Publications of the Molecular Helminthology Lab

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  1. Angeli, A., Pinteala, M., Maier, S.S., Simionescu, B.C., Da’dara, A.A., Skelly, P.J., Supuran, C.T. 2020. Sulfonamide inhibition studies of an α-carbonic anhydrase from Schistosoma mansoni, a platyhelminth parasite responsible for schistosomiasis. International Journal of Molecular Sciences.
  2. Pirovich, D., Da'dara, A.A., Skelly, P.J. 2019. Why Do Intravascular Schistosomes Coat Themselves in Glycolytic Enzymes?. BioEssays.
  3. Da’dara, A.A., Angeli, A., Ferraroni, M., Supuran, C.T., Skelly, P.J. 2019. Crystal structure and chemical inhibition of essential schistosome host-interactive virulence factor carbonic anhydrase SmCA. Communications Biology.
  4. Elzoheiry, M., Da'dara, A.A., Nation, C.S., El-Beshbishi, S.N., Skelly, P.J. 2019. Schistosomes can hydrolyze proinflammatory and prothrombotic polyphosphate (polyP) via tegumental alkaline phosphatase, SmAP. Molecular and Biochemical Parasitology.
  5. Elzoheiry, M., Da'Dara, A.A., Delaforcade, A.M., El-Beshbishi, S.N., Skelly, P.J. 2018. The Essential Ectoenzyme SmNPP5 from the Human Intravascular Parasite Schistosoma mansoni is an ADPase and a Potent Inhibitor of Platelet Aggregation. Thrombosis and Haemostasis.
  6. Wang, Q., Da'Dara, A.A., Skelly, P.J. 2018. The blood fluke Schistosoma mansoni cleaves the coagulation protein high molecular weight kininogen (HK) but does not generate the vasodilator bradykinin. Parasites and Vectors.
  7. Elzoheiry, M., Da'dara, A.A., Bhardwaj, R., Wang, Q., Azab, M.S., El-Kholy, E.-S.I., El-Beshbishi, S.N., Skelly, P.J. 2018. Intravascular Schistosoma mansoni Cleave the Host Immune and Hemostatic Signaling Molecule Sphingosine-1-Phosphate via Tegumental Alkaline Phosphatase. Frontiers in immunology.
  8. Wang, Q., Da'dara, A.A., Skelly, P.J. 2017. The human blood parasite Schistosoma mansoni expresses extracellular tegumental calpains that cleave the blood clotting protein fibronectin. Scientific Reports.
  9. Skelly, P., LoVerde, P.T. 2017. Editorial. Molecular and Biochemical Parasitology.
  10. Da'dara, A.A., Siddons, G., Icaza, M., Wang, Q., Skelly, P.J. 2017. How schistosomes alter the human serum proteome. Molecular and Biochemical Parasitology.
  11. Krautz-Peterson, G., Debatis, M., Tremblay, J.M., Oliveira, S.C., Da’dara, A.A., Skelly, P.J., Shoemaker, C.B. 2017. Schistosoma mansoni Infection of Mice, Rats and Humans Elicits a Strong Antibody Response to a Limited Number of Reduction-Sensitive Epitopes on Five Major Tegumental Membrane Proteins. PLoS Neglected Tropical Diseases.
  12. Da’dara, A.A., de Laforcade, A.M., Skelly, P.J. 2016. The impact of schistosomes and schistosomiasis on murine blood coagulation and fibrinolysis as determined by thromboelastography (TEG). Journal of Thrombosis and Thrombolysis.
  13. Da’dara, A.A., Skelly, P.J. 2015. Gene suppression in schistosomes using RNAi. Methods in Molecular Biology.
  14. Figueiredo, B.C., Da'dara, A.A., Oliveira, S.C., Skelly, P.J. 2015. Schistosomes Enhance Plasminogen Activation: The Role of Tegumental Enolase. PLoS Pathogens.
  15. Da'Dara, A.A., Skelly, P.J. 2014. Schistosomes versus platelets. Thrombosis Research.
  16. Figueiredo, B.C., Assis, N.R.G., Morais, S.B., Ricci, N.D., Pinheiro, C.S., Martins, V.P., Bicalho, R.M., Da'dara, A.A., Skelly, P.J., Oliveira, S.C. 2014. Schistosome Syntenin Partially Protects Vaccinated Mice against Schistosoma mansoni Infection. PLoS Neglected Tropical Diseases.
  17. Skelly, P.J., Da'dara, A.A., Li, X.-H., Castro-Borges, W., Wilson, R.A. 2014. Schistosome Feeding and Regurgitation. PLoS Pathogens.
  18. Da’dara, A.A., Bhardwaj, R., Skelly, P.J. 2014. Schistosome apyrase SmATPDase1, but not SmATPDase2, hydrolyses exogenous ATP and ADP. Purinergic Signalling.
  19. Da'dara, A.A., Bhardwaj, R., Ali, Y.B.M., Skelly, P.J. 2014. Schistosome tegumental ecto-apyrase (SmATPDase1) degrades exogenous pro-inflammatory and pro-thrombotic nucleotides. PeerJ.
  20. Skelly, P.J. 2013. The use of imaging to detect schistosomes and diagnose schistosomiasis. Parasite Immunology.