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Description:

The primary purpose of the study is to determine whether English Bulldogs are more hypercoagulable than non-brachycephalic dogs by running a series of coagulation tests. We are also interested in determining if C-reactive protein, a marker of inflammation and cardiovascular risk, is elevated in English Bulldogs as it is in humans with obstructive sleep apnea.

Inclusion Criteria:

English Bulldogs that have not undergone upper airway surgery and are currently exhibiting clinical signs consistent with the brachycephalic airway syndrome as documented by their owner (loud upper airway noise, snoring).

English Bulldogs that are between 2 and 8 years of age, any sex or weight.

Exclusion Criteria:

English Bulldogs known to have a condition that will affect coagulation status, such as neoplasia, hemolytic anemia or thrombocytopenia.

English Bulldogs taking medication that may affect its coagulation parameters, such as non-steroidal anti-inflammatory drugs, warfarin, low molecular weight heparin, clopidogrel, aspirin, or prednisone.

English Bulldogs that have had surgical correction of their upper airway abnormalities (ie. Palatoplasty and rhinoplasty) to resolve/improve brachycephalic airway signs.

Client Benefits:

The study will cover the costs of routine bloodwork as well as coagulation tests and C-reactive protein analysis. Your dog’s participation will also allow us to gain information which will help in the treatment of other dogs with this condition.

Contact Information:

For questions regarding the clinical trial please email the clinical trials technician, Diane Welsh at: clinicaltrials@tufts.edu