Greice Krautz-Peterson

Dr. Greice Krautz-Peterson is a Research Assistant Professor who received her PhD in Biochemistry and Immunology at Federal University of Minas Gerais, Brazil. During her PhD, in collaborative work at Northwestern University Medical School, Chicago, IL, she identified and expressed Trypanosoma cruzi antigens for evaluating effective treatment of patients with Chagas' disease. In 2004 and 2005, she worked with the research group on diarrheagenic E. coli/HUS associated diseases at the Cummings School of Veterinary Medicine and identified a new intracellular mechanism of shiga toxin neutralization by a human monoclonal antibody; she also characterized antibiotics that increase or inhibit toxin production. Greice joined the Molecular Helminthology lab in 2006 to study the function of enzymes and tegument transporters in the human parasite Schistosoma mansoni, using RNAi. She also worked as a co-investigator to test the capability of Clostridium difficile toxins to efficiently deliver an intracellular therapeutic agent that revert botulinum neurointoxication. Currently, Dr. Krautz-Peterson is the principal investigator of an NIH grant to study the gene function of molecules expressed on the schistosome surface that are likely to protect the parasite against the host’s immune attack. She is also testing fluorescence in vivo imaging as a new technology to study the pathogenesis of E. coli shiga toxins. Her most recent publications are:

  1. Krautz-Peterson G, Zhang Y, Chen K, Oyler GA, Feng H, Shoemaker CB. 2012. Retargeting Clostridium difficile toxin B to neuronal cells as a potential vehicle for cytosolic delivery of therapeutic biomolecules to treat botulism. J Toxicol; 2012:760142
  2. Da'dara A, Faghiri Z, Krautz-Peterson G, Bhardwaj R, Skelly PJ. 2012. Schistosome Na, K-ATPase as a therapeutic target. Trans R Soc Trop Med Hyg. Feb; 107(2):74-82
  3. Da'dara A, Krautz-Peterson G, Faghiri Z, Skelly PJ. 2012. Metabolite movement across the schistosome surface. J Helminthol. Feb 27:1-7.
  4. Bhardwaj R, Krautz-Peterson G, Da'dara A, Tzipori S, Skelly PJ. 2011. Tegumental phosphosdiesterase SmNPP-5 is a virulence factor for schistosomes. Infect Immun. Oct;79(10):4276-84.
  5. Bhardwaj R, Krautz-Peterson G, Skelly PJ. Using RNA Interference in Schistosoma mansoni. 2011. Methods Mol Biol.; 764:223-39.
  6. Krautz-Peterson G, Simoes M, Faghiri Z, Ndegwa D, Oliveira G, Shoemaker CB, Skelly PJ. 2010. Suppressing glucose transporter gene expression in schistosomes impairs parasite feeding and decreases survival in the mammalian host. PLoS Pathog. Jun 3:6(6).
  7. Krautz-Peterson G, D. Ndegwa, K. Vasquez, H. Korideck, J. Zhang, J.D. Peterson, and P.J. Skelly. 2009. Imaging schistosomes in vivo. FASEB J. Aug; 23: 2673-80.