Education |General Research Interest | Selected Research Projects
Research and Clinical Interests |Selected Publications

Cynthia R.L. Webster
Professor, Associate Chair
Department of Clinical Sciences
Internal Medicine
Phone: 508-839-5395
Fax: 508-839-8787

Education

DVM - Cornell University - 1985
BS - Simmons College - 1978

House Officer Training

ACVIM Small Animal Medicine - TCSVM

Board Certification

Diplomate, American College of Veterinary Internal Medicine (Small Animal)

Teaching
  • Gastrointestinal/hepatic pathology/pharmacology
  • Small animal medicine, gastrointestinal/hepatic medicine
  • Clinical rotations, small animal medicine
  • Pathobiology: Cholestasis
General Research Interest
  • Cholestatic liver disease in dogs and cats, bile acid hepatotoxicity, hepatocyte apoptosis/survival signaling.
Research Sponsor Interest
  • Federal and privately funded research.
Selected Research Projects
  • Role of cAMP signaling through cAMP-GEF in hepatocyte survival.
  • Role of bile acid apoptosis in cholestatic liver disease.
  • Novel stem cell intervention in cholestatic liver disease in dogs and cats.
  • Coagulation and liver disease.
Back to the Top

Research & Clinical Interests
  • Signal transduction in hepatocyte apoptosis.
  • Molecular mechanisms of pathogenesis in cholestatic liver disease.
  • Hormonal control of hepatocyte survival.
  • Diagnosis and therapeutic intervention in canine and feline cholestatic liver disease.
Major Specialized Equipment Items Available
  • Fully equipped cell biology laboratory.
  • Isolation and culture of primary hepatocytes.
Selected Publications

  1. Penninck DG, Zeyen U, Taeymans ON, Webster CRL. Ultrasonographic measurement of the pancreas and pancreatic duct in clinically normal dogs.Am J Vet Res. 2013;74:433-7.

  2. Weissman A, Penninck D, Webster CRL, Hecht S, Keating J, Craig LE.Ultrasonographic       and      clinicopathological features of feline gastrointestinal eosinophilic sclerosing fibroplasia in 4        cats  J  Fel Med Surg 2013;15: 148-154.

  3. Park S, Schonhoff C, Webster, CRL, Anwer M.  (2012). Protein kinase Cδ differentially regulates cAMP-dependent translocation of NTCP and MRP2 to the plasma membrane  Am J Physiol2012 303: G657-665.

  4. Respess M, O Toole T, Taeysmans O, Rogers C, Webster CRL. Portal vein thrombosis in dogs J Vet Intern Med J Vet Intern Med. 2012;26(2):230-7

  5. Kavanagh C, Shaw S, Webster CRL.Coagulation in liver disease. J Vet Emer Crit Care J  Vet Emer Crit Care 2011;21: 589–604

  6. Johnston A, Ponzetti K, Anwer MS, Webster CRL. cAMP-guanine exchange factor   protection from  bile acid induced hepatocyte apoptosis involves glycogen synthase kinase regulation of C-Jun- NH terminal kinase  Am J Physiol Gastrointest Liver;2011; 301(2):G385-            G400

  7. Taeymans O, Holt N, Penninck DG, Webster CRL. Ultrasonographic characterization of feline ileocececolic abnormalities.  Vet Radiol Ultrasound. 2011;52(3):335-9

  8. Buob S, Johnston AN, Webster CR. Portal hypertension: pathophysiology, diagnosis, and treatment. J Vet Intern Med. 2011; 25(2):169-86. PMID:21382073.

  9. Hohenester S, Gates A, Wimmer R, Beuers U, Anwer MS, Rust C, Webster CRL. Phosphatidylinositol-3-kinase p110 gamma contributes to bile salt-induced apoptosis in primary rat hepatocytes and human hepatoma cells. J Hepatol. 2010; 53(5):918-26.

  10. Penninck D, Brissan JO, Webster CRL. The sonographic assessment of gallbladder volume in normal cats. Vet Rad Ultrasound. 2010; 51(6):665-6.

  11. Ponzetti K, Anwer SA, King M, Gates A, Webster CRL. Cyclic AMP-guanine exchange factor activation inhibits JNK dependent lipopolysaccharide induced apoptosis in rat hepatocytes. 2010. Hepatic Medicine: Evidence and Research. Hepat Med 2010:.2: 1- 11.

  12. Schonhoff CM, Webster CR, Anwer MS. Cyclic AMP stimulates MRP 2 translocation by activating p38 alpha MAPK in hepatic cells. Am J Physiol Gastrointest Liver Physiol. 2010; 298(5):G667-674. PMID: 20203059.

  13. Schonhoff CM, Yamazaki A, Hohenester S, Webster CR, Bouscarel B, Anwer MS. PKC epsilon-dependent and independent effects of taurolithocholate on PI3K/PKB pathway and taurocholate uptake in Huh7-NTCP cell line. Am J Physiol Gastrointest Liver Physiol. 2009; 297(6):G1259-67. PMID: 19815625.

 

Back to the Top