Education | Laboratory Personnel | General Research Interest | Selected Research Projects
Research and Clinical Interests | Major Specialized Equipment Items Available | Selected Publications
TCSVM Faculty

Charles B. Shoemaker
Professor
Department of Biomedical Sciences
Infectious Diseases
Phone:508-887-4324
Fax: 508-839-7911
Email: charles.shoemaker@tufts.edu
Division URL: http://vet.tufts.edu/biomed/infectious_diseases.htm
Dept. URL: http://www.tufts.edu/vet/dbs/
Lab URLs:
 Molecular Helminthology Lab
 Microbiology and Botulism Research Unit
 Shoemaker/Skelly Lab

Education
PhD - University of Iowa - 1979
BS - University of NH - 1975

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Laboratory Personnel

Shoemaker/Skelly Lab:

  • Dr. Greice Krautz-Peterson
  • Dr. Akram d'Adara
  • Ms. Rita Bhardwaj
  • Ms. Jacque Tremblay
  • Ms. Michelle Debatis


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General Research Interest

Research Sponsor Interest

  • Privately Funded Research
  • Federally Funded Research
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Selected Research Projects

  1. Probing the helminth host/parasite interface with phage-displayed antibodies
  2. Tagged binding agents as anti-toxin therapeutics
  3. New small molecule anti-toxin drugs
  4. Agents that target toxins for proteasome degradation
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Selected Publications

  1. Krautz-Peterson, Oyler GA, Feng H, Shoemaker CB. 2012. Retargeting Clostridium difficile toxin B to neuronal cells as a potential vehicle for cytosolic delivery of therapeutic biomolecules to treat botulism. J. Toxicol. 2012:760142.

  2. Mukherjee J, Tremblay JM, Leysath CE, Ofori K, BaldwinK, Feng X, Bedenice D, Webb RP, Wright PM, Smith LA, Tzipori S, Shoemaker CB. 2012. A novel strategy for development of recombinant antitoxin therapeutics tested in a mouse botulism model. PLoS ONE. 7(1):e29941.

  3. Gu S, Rumpel S, Zhou J, Strotmeier J, Bigalke H, Perry K, Shoemaker CB, Rummel A, Jin R. 2012. Botulinum neurotoxin is shielded by NTNHA in an interlocked complex. Science. 335:977-981.

  4. Kuo CL, Oyler GA, Shoemaker CB. 2011. Accelerated neuronal cell recovery from botulinum neurotoxin intoxication by targeted ubiquitination. PLoS ONE. 6(5):e20352.

  5. Silhár P, Alakurtti S, Capková K, Xiaochuan F, Shoemaker CB, Yli-Kauhaluoma J, Janda KD. 2011. Synthesis and evaluation of library of betulin derivatives against the Botulinum neurotoxin A protease. Bioorg Med Chem Lett. 21:2229-31.

  6. Tsai YC, Maditz R, Kuo CL, Fishman PS, Shoemaker CB, Oyler GA, Weissman AM. 2010. Targeting botulinum neurotoxin persistence by the ubiquitin-proteasome system. Proc. Natl. Acad. Sci. USA. 107:16554-9. PMCID: PMC2944746.

  7. Tremblay JM, Kuo CL, Abeijon C, Sepulveda J, Oyler G, Hu X, Jin MM, Shoemaker CB. 2010. Camelid single domain antibodies (VHHs) as neuronal cell intrabody binding agents and inhibitors of Clostridium botulinum neurotoxin (BoNT) proteases. Toxicon. 56:990-8. PMCID: PMC2946066.

  8. Eubanks LM, Silhar P, Salzameda NT, Zakhari JS, Xiaochuan F, Barbieri JT, Shoemaker CB, Hixon MS, Janda KD. 2010. Identification of a Natural Product Antagonist against the Botulinum Neurotoxin Light Chain Protease. ACS Med. Chem. Lett. 1:268-272. PMCID: PMC2955888

  9. Krautz-Peterson G, Simoes M, Faghiri Z, Ndegwa D, Oliveira G, Shoemaker CB,  Skelly PJ. 2010. Suppressing glucose transporter gene expression in schistosomes impairs parasite feeding and decreases survival in the mammalian host. Plos Pathogens. 6:e1000932. PMCID: PMC2880588.

  10. Sepulveda J, Tremblay JM, Skelly PJ, Shoemaker CB. 2010. Schistosoma mansoni host-exposed surface antigens characterized by sera and recombinant antibodies from schistosomiasis resistant rats. Int. J. Parasitol. 40:1407-17. PMCID: PMC2939210.

  11. Sepulveda J, Mukherjee J, Tzipori S, Simpson LL, Shoemaker CB. 2010. Efficient serum clearance of Botulinum neurotoxin achieved using a pool of small antitoxin binding agents. Infection and Immunity. 78:756-63. PMCID: PMC2812214.

  12. Kuo CL, Oyler G, Shoemaker CB. 2010. Lipid and cationic polymer based transduction of botulinum holotoxin, or toxin protease alone, extends the target cell range and improves the efficiency of intoxication. Toxicon. 55:619-29. PMCID: PMC2813905.

  13. Maass DR, Harrison GB, Grant WN, Hein WR, Shoemaker CB. 2009. Intraspecific epitopic variation in a carbohydrate antigen exposed on the surface of Trichostrongylus colubriformis infective L3 larvae. PLoS Pathogens. Sep;5:e1000597. PMCID:  PMC2742895.  

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