Abhineet S. Sheoran
The Usen Family Career Development Assistant Professor
Department of Infectious Disease and Global Health
Dept. URL: http://www.tufts.edu/vet/dbs/infectious_diseases/
PhD - University of Cambridge, England - 1996
MVSc - Haryana Agricultural University, India - 1991
BVSc & AH - Haryana Agricultural University, India - 1989
General Research Interest
Microbial pathogenesis, immune response against microbial pathogens, immunotherapy, vaccine development, and equine immunology.
The focus of research is on bacterial and protozoan pathogens of zoonotic importance that induce enteric disease. We are investigating the nature of host-parasite interaction of Cryptosporidium spp. with respect to disease manifestation, pathogenesis, and immunity. We are also investigating the pathogenesis of disease caused by Shiga toxin producing Escherichia coli (STEC), and developing immunotherapy for prevention of hemolytic-uremic syndrome, a complication of STEC infection and a leading cause of acute renal failure in young children.
Research Sponsor Interest
- Federally Funded Research
- Privately Funded Research
Selected Research Projects
Pathogenic and immunogenic studies on Cryptosporidium genotypes.
Antibody therapy in Stx intoxication and clearance of Stx/antibody complexes.
Stx-Specific Human Monoclonal Antibodies for HUS Prophylaxis.
Major Specialized Equipment Items Available
- ELISA plate washer
- Nanodrop ND-1000 spectrophotometer
- Phase contrast microscope
- Lecturer and Director of the Immunology course (VET 109) for first year veterinary students.
- Lecturer in the Parasite Biology course (VET 652) for graduate students.
Challa S, Nally JE, Jones C, Sheoran AS. 2011. Passive immunization with Leptospira LPS-specific agglutinating but not non-agglutinating monoclonal antibodies protect guinea pigs from fatal pulmonary hemorrhages induced by serovar Copenhageni challenge. Vaccine. 29: 4431-4.
- Jeong KI, Tzipori S, Sheoran AS. 2010. Shiga toxin 2-specific but not Shiga toxin 1-specific human monoclonal antibody protects piglets challenged with enterohemorrhagic Escherichia coli producing Shiga toxin 1 and Shiga toxin 2. J Infect Dis. 201(7):1081-1083.
- Jeong KI, Chapman-Bonofiglio S, Singh P, Lee J, Tzipori S, Sheoran A. 2010. In vitro and in vivo protective efficacies of antibodies that neutralize the RNA Nglycosidase activity of Shiga toxin 2. BMC Immunol. 11(1):16.<
- Krautz-Peterson G, Chapman-Bonofiglio S, Boisvert K, Feng H, Herman IM, Tzipori S, Sheoran AS. 2008. Intracellular neutralization of Shiga toxin 2 by an A subunit-specific human monoclonal antibody. Infect Immun. (in press).
- Feng H, Nie W, Sheoran A, Zhang Q, Tzipori S. 2006. Bile Acids Enhance Invasiveness of Cryptosporidium spp. into Cultured Cells. Infect Immun. 74:3342-6
- Sheoran AS, Feng X, Singh I, Chapman-Bonofiglio S, Kitaka S, Hanawalt J, Nunnari J, Mansfield K, Tumwine JK, Tzipori S, 2005. Monoclonal Antibodies against Enterocytozoon bieneusi of human origin. J Clin Diag Lab Immunol. 12: 1109-13.
- Sheoran AS, Chapman-Bonofiglio S, Harvey BR, Mukherjee J, Georgiou G, Donohue-Rolfe A, Tzipori S. 2005. Human antibody against shiga toxin 2 administered to piglets after the onset of diarrhea due to Escherichia coli O157:H7 prevents fatal systemic complications. Infect Immun. 73: 4607-13.
- Tzipori S, Sheoran AS, Akiyoshi D, Donohue-Rolfe A, Trachtman H. 2004. Antibody therapy in the management of shiga toxin-induced hemolytic uremic syndrome. Clinical Microbiol Reviews. 17: 926-41.
- Sheoran AS, Chapman S, Singh P, Donohue-Rolfe A, Tzipori S. 2003. Stx2-specific human monoclonal antibodies protect mice against lethal infection with Escherichia coli expressing Stx2 variants. Infect Immun. 71:3125-30.
- Sheoran, A.S., Timoney J.F., Holmes, M.A., Karzenski, S., and Crisman M.V., 2000. Immunoglobulin isotypes in equine sera and nasal mucosal secretions and their neonatal transfer and distribution. Am. J. Vet. Res. 61: 1099-1105.