TCSVM Faculty

Satyapriya Sarkar
Professor
Department of Biomedical Sciences
Developmental and Molecular Biology
Phone: 617-636-2931
Fax: 617-636-6536
Email: satyapriya.sarkar@tufts.edu
Personal URL: http://www.tufts.edu/sackler/cmdb/sarkar-lab.htm
Dept. URL: http://www.tufts.edu/med/anatomy/

Education
PhD - Northwestern University - 1961
MS - University of Calcutta, India - 1956
BS (Hons.) - University of Calcutta, India - 1953

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Laboratory Personnel
Monalisa Mukherjea, M.S., Graduate Student
Tathagata Chaudhuri, M.S., Graduate Student
Subhradip Mukhopadhyay, M.S., Graduate Student

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General Research Interest
My laboratory has been engaged in studies on the biochemistry and molecular biology of vertebrate striated muscle since 1969. The research, continuously funded by NIH for the period of 1969-2003, spans various aspects of muscle biology (see also publications).

Research Sponsor Interest

  • Privately Funded Research
  • Federally Funded Research
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Selected Research Projects
Current studies include the evolution of vertebrate striated muscle genes, the regulation of gene expression in muscle cell during development, structure of human muscle genes and their expression in normal and pathological conditions, and mechanism of Ca-regulated muscle contraction by using mutant muscle proteins.

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Research and Clinical Interests

  • Genetic aspects of infantile dilated cardiomyopathy in Portuguese Water Dogs

  • Anti-angiogenesis activity of thin filament muscle proteins

  • Structure and function of troponin complex

  • Evolution of multigene families of contractile proteins

  • Mechanism of Ca regulation of muscle contraction

  • Role of troponin T in thin filament function

  • Coiled coil interactions of muscle proteins

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Major Specialized Equipment Items Available
PCRl; Fluorescence Spectrophotometer; Hybridization Chamber for genomic and cDNA hybridization; other standard equipment for DNA, RNA and protein work

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Selected Publications

  1. Stefancsik, R. and Sarkar, S. 2003. Relationship between the DNA binding domains of SMAD and NFI/CT F transcription factors defines a new superfamily of genes. DNA Sequence 14:233-239.

  2. Sachdev, S., Raychowdhury, M.K. and Sarkar, S. 2003. Human fast skeletal myosin light chain 2 cDNA: Isolation, tissue specific expression of the single copy gene, comparative sequence analysis of isoforms and evolutionary relationships. DNA Sequence 14: 339-350.

  3. Stefancsik, R., Randall, J.D. and Sarkar, S. 2003. Structure and sequence of human fast skeletal troponin T (TNNT3) gene: Insight into the evolution of the gene and origin of the developmentally regulated isoforms. Comparative and Functional Genomics 4: 609-625.

  4. Alroy, J., Rush, J.E., Freeman, L. , Kumar, M.S.A., Karuri, A., Chase, K., Sarkar, S. 2000. Inherited Infantile Dilated Cardiomyopathy in Dogs: Genetic, Clinical, Biochemical and Morphological Findings. Am. J. Med. Genetics 95:57-66. Web page of publications: http://www.cos.com

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