Education | Laboratory Personnel | General Research Interest | Selected Research Projects
Research and Clinical Interests | Major Specialized Equipment Items Available | Selected Publications
TCSVM Faculty

Jong-Beak Park
Research Assistant Professor
Manager of Botulinum Program
Department of Biomedical Sciences
Infectious Diseases
Phone: 508-887-4265
Fax: 508-887-4576
Email: jong_beak.park@tufts.edu
Dept. URL: http://vet.tufts.edu/biomed/infectious_diseases.htm

Education
PhD - Toyama Medical & Pharmaceutical University, Japan - 1996
MS - College of Pharmacy, KyungHee University - 1993
BS - College of Pharmacy, KyungHee University - 1989

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General Research Interest
Botulinum toxin is the etiologic agent responsible for the disease botulism, which is characterized by peripheral neuromuscular blockade. There are 7 distinct but related neurotoxins, A through G, produced by different strains of the clostridial bacillus. Botulinum toxin poses a major bioweapon threat because of its extreme potency and lethality. There is a need to generate a pharmaceutical to prevent or treat botulism. The research activity has been focused on:

  1. Development of antitoxin therapy against all possible routes of botulinum toxin intoxication
  2. Development of therapeutic agents against botulism using high throughput screening

Research Sponsor Interest

  • Federally Funded Research
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Selected Publications

  1. Jong-Beak Park, L. L. Simpson, Intranasal Immunization against botulinum toxin (Review), Expert Review of Vaccines, in submission, 2004

  2. LL Simpson, AB Maksymowych, Jong-Beak Park, RS Bora, The role of the interchain disulfide bond in governing the pharmacological action of botulinum toxin, J. Pharm. Exp. Ther., 308(3), 857-64, 2004

  3. Jong-Beak Park, L. L. Simpson, Inhalation poisoning by botulinum toxin and inhalation vaccination by its heavy chain component, Infect. Immun., 71(3), 1147-1154, 2003

  4. Jong-Beak Park, L. L. Simpson, R. Sataloff, Immunologic characterization of spasmodic dysphonia patients who develop resistanct to botulinum toxin, J. Voice, 17(2), 255-264, 2003

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Patent Information

  1. Simpson, L.L., Maksymowych A.B., Jong-Beak Park: Compositions and Methods for Transepithelial Molecular Transport. (pending for U.S. and International patent).

  2. Jong-Beak Park and Cheil Food & Chemical Inc., Registered in Korea patent rolls on Jan. 12th, 2000, Urease Containing Vaccine against Helicobacter pylori infection (Patent No. #0251391)

  3. Jong-Beak Park and Cheil Food & Chemical Inc., International patent pending (application number: PCT/KR 98/00216, filing number WO 00/03730), Urease Based Vaccine against Helicobacter Infection

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