Andrew M. Hoffman, DVM, DVSc, DACVIM
Professor, Large Animal Internal Medicine
Department of Clinical Sciences
Director, Lung Function Regeneration Laboratory
DVSc - University of Guelph, Ontario Veterinary College - 1990
DVM - Cornell University - 1985
ACVIM (Large Animal Medicine)
Airiel Davis, Research Assistant
Research Sponsor Interest
- NIH (NHLBI/NIA)
- Pulmonary Physiology
- Cellular and Molecular Biology
- Regenerative Medicine
Stem cells and organ regeneration
The cellular and molecular basis for organ regeneration with emphasis on lung; role of stem / progenitor cells in lung regeneration; molecular basis for self-renewal and differentiation in lung stem cells; growth signaling pathways initiated by mesenchymal stem cells in the lung (LMSCs.
Veterinary and translational research
Devices for pulmonary function testing; diagnosis of inflammatory airway disease using bronchoalveolar cytology; aerosol delivery devices; respiratory physiology of marine mammals; non-surgical lung volume reduction; cell-based therapies.
Pacheco A, Bedenice D, Mazan M, and Hoffman AM. (2011) Respiratory mechanics and bronchoalveolar lavage in healthy adult alpacas. Am J Vet Res, in press, Jan 2012. doi: 10.2460/ajvr.73.1.146
Paxson J, Gruntman A, Parkin C, Mazan M, Davis A, Ingenito E, and Hoffman AM (2011). Age dependent decline in lung regeneration with loss of clonogenicity and myofibroblast differentiation of lung fibroblasts. PlosOne, Published August 30, 2011 10.1371/journal.pone.0023232.
Pritchard S, Hoffman AM, Johnson KL, Bianchi DW (2011). Pregnancy-associated progenitor cells: An under-recognized potential source of stem cells in maternal lung. Placenta [Epub ahead of print], PMID: 21546085. Published On-Line April 7, 2011.
Hoffman AM, Paxson J, Mazan M, Davis A, Tyagi S, Murthy S, and Ingenito EP (2011). Lung mesenchymal stromal cell post-transplantation survival, persistence, paracrine expression, and repair of elastase injured lung. Stem Cells Develop, DOI: 10.1089/scd.2011.0105; PMID 21585237. Published Sept 28, 2011.
Ingenito EP, Tsai L, Murthy S, Mazan MR, and Hoffman AM (2011). Autologous lung mesenchymal stem cell transplantation in an emphysema model. Cell Transplant, Feb 3, ePub ahead of print;PMID 21294955.
Hoffman AM, Shifren A, Mazan MR, Gruntman AM, Lascola K, Nolen-Walston R, Kim CF, Tsai L, Pierce RA, Mecham R, and Ingenito EP (2010). Matrix modulation of compensatory lung regrowth and progenitor cell proliferation in mice. Am J Physiol: Lung Cell Mol Physiol 298:L158-68; PMID 19915155.
Ingenito EP, Sen E, Tsai L, Murthy S, Hoffman AM (2010). Design and testing of biological scaffolds for delivery reparative cells to target sites in the lung. J Tiss Eng Reg Med 4:259-272; PMID: 20020503.