Education | Laboratory Personnel | General Research Interest
Research and Clinical Interests | Selected Publications
TCSVM Faculty

Andrew M. Hoffman, DVM, DVSc, DACVIM
Professor, Large Animal Internal Medicine
Department of Clinical Sciences
Director, Lung Function Regeneration Laboratory
Phone: 508-887-4589
Fax: 508-887-4213
Email: andrew.hoffman@tufts.edu

Education
DVSc - University of Guelph, Ontario Veterinary College - 1990
DVM - Cornell University - 1985

Board Certification
ACVIM (Large Animal Medicine)

Laboratory Personnel:

Airiel Davis, Research Assistant

Research Sponsor Interest:

  • NIH (NHLBI/NIA)
  • Biotech
  • Pharma
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Clinical Interests:

  • Pulmonary Physiology
  • Cellular and Molecular Biology
  • Regenerative Medicine

Research Interests:

Stem cells and organ regeneration

The cellular and molecular basis for organ regeneration with emphasis on lung; role of stem / progenitor cells in lung regeneration; molecular basis for self-renewal and differentiation in lung stem cells; growth signaling pathways initiated by mesenchymal stem cells in the lung (LMSCs.

Veterinary and translational research

Devices for pulmonary function testing; diagnosis of inflammatory airway disease using bronchoalveolar cytology; aerosol delivery devices; respiratory physiology of marine mammals; non-surgical lung volume reduction; cell-based therapies.

 

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Recent Publications:

  1. Nolen-Walston RD, Kim CF, Mazan MR, Ingenito EP, Gruntman AM, Tsai L, Boston R, Woolfenden AE, Jacks T, and Hoffman AM (2008).  Cell kinetics and modeling of bronchioalveolar stem cell proliferation during lung regeneration in mice.  Am J Physiol: Lung Cell Mol Biol;294: L1158-L1165; PMID 18375744.

  2. Nolen-Walston RD, Boston RC, Wilkins PA, Mazan MR, Kuehn H, and Hoffman AM. (2009) Reproducibility of airway responsiveness measuring using flowmeteric plethysmography and histamine bronchoprovocation in horses.   J Vet Int Med 2009; 23;631-635.

  3. Rozanski EA, Bedenice D, Lofgren J, Abrams J, Bach J, Hoffman AM. (2010).   The effect of body position, sedation, and thoracic bandaging on functional residual capacity in healthy deep-chested dogs.  Can J Vet Res;74:34-9.

  4. Paxson J, Parkin C, Iyer L, Mazan MR, Ingenito EP, and Hoffman AM (2009).   Global gene expression patterns during post-pneumonectomy lung regeneration in adult mice.   Resp Research 10:92; PMID 19804646

  5. Ingenito EP, Sen E, Tsai L, Murthy S, Hoffman AM (2010).  Design and testing of biological scaffolds for delivery reparative cells to target sites in the lung.  J Tiss Eng Reg Med   4:259-272; PMID: 20020503.

  6. Hoffman AM, Shifren A, Mazan MR, Gruntman AM, Lascola K, Nolen-Walston R, Kim CF, Tsai L, Pierce RA, Mecham R, and Ingenito EP (2010).  Matrix modulation of compensatory lung regrowth and progenitor cell proliferation in mice   Am J Physiol: Lung Cell Mol Physiol  298:L158-68; PMID 19915155.

  7. Ingenito EP, Tsai L, Murthy S, Mazan MR, and Hoffman AM (2011).   Autologous lung mesenchymal stem cell transplantation in an emphysema model. Cell Transplant, Feb 3, ePub ahead of print;PMID 21294955.

  8. Hoffman AM, Paxson J, Mazan M, Davis A, Tyagi S, Murthy S, and Ingenito EP (2011).  Lung mesenchymal stromal cell post-transplantation survival, persistence, paracrine expression, and repair of elastase injured lung.  Stem Cells Develop, DOI: 10.1089/scd.2011.0105; PMID 21585237.

  9. Pritchard S, Hoffman AM, Johnson KL, Bianchi DW (2011).  Pregnancy-associated progenitor cells: An under-recognized potential source of stem cells in maternal lung.  Placenta  [Epub ahead of print], PMID: 21546085.

  10. Paxson J, Gruntman A, Parkin C, Mazan M, Davis A, Ingenito E, and Hoffman AM (2011).  Age dependent decline in lung regeneration with loss of clonogenicity and myofibroblast differentiation of lung fibroblasts.  PlosOne, published 30 Aug 2011 10.1371/journal.pone.0023232.