Education | Laboratory Personnel | General Research Interest | Selected Research Projects
Research and Clinical Interests | Major Specialized Equipment Items Available | Selected Publications
TCSVM Faculty

Daniela Bedenice
Associate Professor
Department of Clinical Sciences
Large Animal Medicine
Phone: 508-839-7926
Fax: 508-839-7931
Email: daniela.bedenice@tufts.edu

Education
Dr. med. vet. - Free University of Berlin, Germany - 1997

Board Certification
Diplomate ACVIM (Large Animal) - 2002
Diplomate ACVECC (Equine) - 2005

General Research Interest
Comparative respiratory physiology and non-invasive pulmonary function testing (equine, canine, camelid). Large animal neonatal and adult critical care. Emerging infectious diseases in camelids.

Research Sponsor Interest

  • Privately Funded Research
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Selected Research Projects

  1. Characterization of immune responses in juvenile alpacas persistently infected with BVDV. Alpaca Research Foundation (ARF).

  2. The cardiovascular effects of dobutamine infusion in healthy, adult, anesthetized alpacas. Empire Alpaca Association.

  3. The humoral response to EEE vaccination in healthy alpacas. (ARF).

  4. Non-invasive measurement of respiratory resistance (Rrs) using two different oscillatory methods in the horse: Comparative study of impulse oscillometry (IOS) and Monofrequency Forced Oscillatory Mechanics (FOM) in the adult horse, pre and post bronchodilation.

  5. Non-invasive measurement of airway resistance (Raw) and functional residual capacity (FRC) in conscious sheep and dogs.

  6. Respiratory mechanics in awake adult llamas.

Research and Clinical Interests

  • Non-invasive pulmonary function testing (horses, dogs, camelids)

  • Comparative respiratory physiology

  • Large Animal Neonatal and Adult Critical Care (horses, camelids)

  • Advanced Medical Care for Equine and Camelid species (llama, alpaca)

  • Emerging infectious diseases in camelids (Eastern Equine Encephalitis, BVD)
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Major Specialized Equipment Items Available
Pulmonary Mechanics Data Acquisition System - XA BioSystem ; Whole Body Plethysmograph ; Canine (Head-Out) Plethysmograph; small Canine Whole Body (unrestrained) Plethysmograph (measurement of PENH); inductance plethysmography (Respitrace ) for measurements of abdominal and rib cage ventilation and thoracoabdominal synchrony; Helium and Carbon Monoxide Monitor (Morgan Scientific - measurement of diffusion capacity of CO and helium dilution using rebreathing, steady state, or single breath method); ventilators; Indirect Calorimeter (Vmax, ViaSys) - resting and exercise energy (VO2, VCO2, RQ), Sato High Speed Treadmill for exercise studies in horses, sheep, dogs, etc.; patient monitoring system (Passport II ), Arterial Blood Gas Analyzer; Computed Tomography (Pickard 5000 Spiral CT and densitometry software); video endoscopy/gastroscopy etc. Clinical pathology, pathology, ultrasound and radiology facilities complement the environment.

Selected Publications

  1. Vincent C, Hawley A, Rozanski E, Lascola K, Bedenice D. Cardiovascular effects of dobutamine and norepinephrine infusion in healthy, anesthetized alpacas. AJVR, under review 2008.
  2. Paxson JA, Cunningham S, Rush J, Bedenice D. “The effect of plasma volume expansion on cardio-vascular function in neonatal crias with PFT”. JVECC, in press 2008.
  3. Bedenice D, Bright A, Pedersen D, Dibb J. “Humoral response to Equine Eastern Encephalitis vaccination in healthy alpacas”. JAVMA, in press 2008.
  4. Bedenice D, Mazan MR, Hoffman AM. Association between cough and cytology of bronchoalveolar lavage fluid and pulmonary function in horses diagnosed with inflammatory airway disease. JVIM. 2008 Jul-Aug; 22(4):1022-8
  5. Bedenice D. Evidence-based medicine in equine critical care. Vet Clin North Am Equine Pract. 2007 Aug;23(2):293-316.
  6. Bach J, Rozanski E, Bedenice D et al. Association of expiratory airway dysfunction with marked obesity in healthy adult dogs. AJVR. Jun;68(6):670-5, 2007.
  7. Lascola K, Hoffman AM, Bedenice D. Respiratory mechanics in sedated and nonsedated adult llamas. AJVR. Jun;68(6):676-84, 2007
  8. Nolen-Walston R, Bedenice D, S, Rodriguez C et al. Eastern equine encephalitis in 9 South American camelids. JVIM. Jul-Aug;21(4):846-52, 2007
  9. Bedenice D, Rozanski E., Bach J, Lofgren J. and Hoffman AM. Canine awake head-out plethysmography (HOP): characterization of external resistive loading and spontaneous laryngeal paralysis. Respir Physiol Neurobiol; 151(1):61-73, 2006.
  10. Bedenice D, Bar-Yishay E, Ingenito E, Tsai L, Hoffman A. “Head-out constant volume plethysmography for the non-invasive measurement of airway resistance [Raw] in conscious sheep”. AJVR, 65(9):1259-1264, 2004.
  11. Bedenice D, Heuwieser W, Solano M, Rand W, Paradis MR. “Risk factors and prognostic variables for survival of foals with radiographic evidence of pulmonary disease”, JVIM, 17:868-875, 2003.
  12. Bedenice D, Heuwieser W, Brawer R, Solano M, Rand W, Paradis MR. “The clinical and prognostic significance of radiographic pattern, distribution and severity of thoracic radiographic changes in neonatal foals”, JVIM, 17:876-886, 2003.
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